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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK1
All Species:
21.52
Human Site:
S333
Identified Species:
33.81
UniProt:
O14757
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14757
NP_001107593.1
476
54420
S333
S
L
W
D
T
S
P
S
Y
I
D
K
L
V
Q
Chimpanzee
Pan troglodytes
XP_001145968
476
54387
S333
S
L
W
D
T
S
P
S
Y
I
D
K
L
V
Q
Rhesus Macaque
Macaca mulatta
XP_001111357
476
54432
S333
S
L
W
D
T
S
P
S
Y
I
D
K
L
V
Q
Dog
Lupus familis
XP_852191
460
52810
S317
S
V
W
D
T
S
P
S
Y
I
D
K
L
V
Q
Cat
Felis silvestris
Mouse
Mus musculus
O35280
476
54363
S333
S
L
W
D
T
G
P
S
N
V
D
K
L
V
Q
Rat
Rattus norvegicus
Q91ZN7
476
54410
S333
S
L
W
D
T
G
P
S
N
V
D
K
L
V
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513209
476
53924
A333
S
L
G
D
S
G
P
A
D
I
D
K
L
V
Q
Chicken
Gallus gallus
Q8AYC9
476
53830
G333
A
L
W
D
S
S
T
G
S
I
D
R
L
V
Q
Frog
Xenopus laevis
Q6DE87
474
53957
I332
W
D
S
N
S
S
Y
I
D
N
L
V
Q
G
K
Zebra Danio
Brachydanio rerio
NP_956487
410
46756
C284
V
S
F
S
Q
P
T
C
P
D
H
M
L
L
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61661
512
57815
V345
R
S
D
D
D
F
N
V
R
L
G
S
G
R
S
Honey Bee
Apis mellifera
XP_623436
467
53927
I331
S
F
S
Q
P
A
H
I
E
D
L
L
L
C
T
Nematode Worm
Caenorhab. elegans
Q9N3Z3
503
56917
L353
P
T
K
T
E
D
L
L
L
T
Q
H
I
D
M
Sea Urchin
Strong. purpuratus
NP_001091925
468
52554
A333
S
V
E
E
L
V
N
A
F
S
F
S
Q
P
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84VQ3
439
49610
D294
D
V
D
A
V
F
K
D
S
E
E
H
H
V
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.3
93.2
N.A.
93.2
94.3
N.A.
89.9
84.4
77.7
56.9
N.A.
46
45.5
32
57.9
Protein Similarity:
100
100
99.7
95.1
N.A.
97
97.2
N.A.
95.3
91.5
86.7
71
N.A.
62.8
63.8
48.7
73.3
P-Site Identity:
100
100
100
93.3
N.A.
80
80
N.A.
66.6
60
6.6
6.6
N.A.
6.6
13.3
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
80
80
26.6
20
N.A.
13.3
20
6.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
0
7
0
14
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% C
% Asp:
7
7
14
60
7
7
0
7
14
14
54
0
0
7
0
% D
% Glu:
0
0
7
7
7
0
0
0
7
7
7
0
0
0
0
% E
% Phe:
0
7
7
0
0
14
0
0
7
0
7
0
0
0
0
% F
% Gly:
0
0
7
0
0
20
0
7
0
0
7
0
7
7
7
% G
% His:
0
0
0
0
0
0
7
0
0
0
7
14
7
0
0
% H
% Ile:
0
0
0
0
0
0
0
14
0
40
0
0
7
0
7
% I
% Lys:
0
0
7
0
0
0
7
0
0
0
0
47
0
0
7
% K
% Leu:
0
47
0
0
7
0
7
7
7
7
14
7
67
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
7
% M
% Asn:
0
0
0
7
0
0
14
0
14
7
0
0
0
0
0
% N
% Pro:
7
0
0
0
7
7
47
0
7
0
0
0
0
7
0
% P
% Gln:
0
0
0
7
7
0
0
0
0
0
7
0
14
0
54
% Q
% Arg:
7
0
0
0
0
0
0
0
7
0
0
7
0
7
0
% R
% Ser:
60
14
14
7
20
40
0
40
14
7
0
14
0
0
7
% S
% Thr:
0
7
0
7
40
0
14
0
0
7
0
0
0
0
14
% T
% Val:
7
20
0
0
7
7
0
7
0
14
0
7
0
60
0
% V
% Trp:
7
0
47
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
0
27
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _